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World of Software > Computing > The Agentic Entrepreneur: How the next wave of AI is changing the startup playbook
Computing

The Agentic Entrepreneur: How the next wave of AI is changing the startup playbook

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Last updated: 2025/10/04 at 11:41 AM
News Room Published 4 October 2025
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The Agentic Entrepreneur: How the next wave of AI is changing the startup playbook
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This week on the GeekWire Podcast: A deep dive on the ways that AI and agents are changing how companies are created, built, and operated.

We’re on location at Pioneer Square Labs in Seattle with investor and entrepreneur T.A. McCann, managing director at the startup studio and venture capital firm.

He explains how AI agents are automating complex functions, letting small teams do the work that once required large groups of people. As AI makes product development easier, he says, the key strategic moat for many startups is now shifting to distribution and data.

Other topics include:

  • The wearable AI recorder (Limitless) that captures everything he says throughout the day.
  • The rise of the one-person billion-dollar company, powered by specialized AI agents.
  • How AI-generated personas are replacing human focus groups for market research.
  • The future of agent-to-agent interactions, where different AI systems work and even negotiate with each other on behalf of people and companies.

PSL companies and projects discussed:

  • The Spark ideation platform;
  • Enzzo, AI-assisted hardware product development;
  • Atrieon, AI project management for software development;
  • Picco, AI-powered workflow automation;
  • Read.AI, meeting transcription/insights (PSL is an investor);
  • Whispers, an internal tool that T.A. uses to prep for meetings

Other tools and startups mentioned include BluePill for AI-persona market research; Gumshoe for optimizing content for AI search; the AI code editor Cursor as an example of product-led growth; and Bloks for AI-powered relationship management.

With GeekWire co-founder Todd Bishop; Edited by Curt Milton.

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